讲授课程

基础有机化学（双语）（专业基础课）；生活化学实验及原理（优质通识课）；
 

有机化学的魅力（新生研讨课）；化学前沿与挑战（博士学位基础课负责人）

研究兴趣

1）化学生物学：有机小分子非病毒基因载体和荧光探针的设计合成及性能研究；药物缓释体系的设计及性能研究；生物活性小分子荧光探针设计合成及性能研究。
 

2）超分子化学：分子拉链的设计合成及肽的折叠组装研究；刚性大环的设计合成及其可控自组装。
 

3）应用开发：工业废水处理，药物中间体研制。

代表性论文

1. Sun, X.-Y.; Zhong, Y.; Li, Y.-H.; Miller, D. P.; Buttan, S.; Wu, X.-X.; Zhang, Y.; Tang, Q.; Tan, H.-W.; Zhu, J.; Liu, R.; Zurek, E.; Lu Z.-L.*; Gong, B.* Reliable folding of hybrid tetrapeptides into short β-hairpins. Chin. Chem. Lett. , 2021, Ahead of Print.
2. Liu, X.-Y.; Yang, J.-B.; Duan, T.-T.; Wu, C.-Y.; Tang, Q.; Lu Z.-L.*; He, L.*; Sun, W.* Degradable cationic polyesters via ring-opening copolymerization of valerolactones as nanocarriers for the gene delivery. Biorg. Chem., 2021, 116, 105299.
3. Liu, M.-X.; Liu, X.-Y.; Liu, J.-Y.; Tang, J.-T.; Shi, K.; Mao, J.; Lu Z.-L.*; Qiao, H.-J.*; He, L.* Di[12]aneN3-functionalized green fluorescent protein chromophore for GFP luminescence simulation and efficient gene transfection in vitro and in vivo. ACS Appl. Bio. Mater., 2021, 4(9), 7111-7112.
4. Tang, F.; Liu, J.-Y.; Wu, C.-Y.; Liang, Y.-X.; Lu Z.-L.*; Ding, A.-X.*; Xu, M.-D.* Two-photon near-infrared AIE luminogens as multifunctional gene carriers for cancer theranostics. ACS Appl. Mater. Interf., 2021, 13, 23384-23395.
5. Tang, F.; Gao, C.; Liu, J.-Y.; Lu Z.-L.*; He, L.*; Ding, A.-X.* Lysosome-targeting BODIPY-derived Hantzsch ester for nitric oxide detection and imaging in live cells. Sens. & Actu., B: Chem., 2021, 339, 129880.
6. Sun, X.-Y.; Liang, Y.-X.; Wu, C.-Y.; Tang, Q.; Liu, R.*; Lu Z.-L.*; He, L.* Nitroreductase-responsive polymeric micelles based on 4-nitrobenzyl and AIE moieties for intracellular doxorubicin release.. Poly. Chem., 2021, 12, 2618-2626.
7. Liu, J.-Y.; Liu, X.-Y.; Liu, R.; Tang, F.; Yang, J.-B.; Tang, Q.; Lu Z.-L.*; Qiao, H.-J.*; He, L.* Integration of [12]aneN3 and Acenaphtho[1,2-b]quinoxaline as non-viral gene vectors with two-photon property for enhanced DNA/siRNA delivery and bioimaging. Bioorg. Chem., 2021, 113, 104983.
8. Zhong, Y. L.; Tang, Q.; Miller, D. P.; Zurek, E.; Liu, R.; Lu Z.-L.*; Gong, B.* Major factors for the persistent folding of hybrid α, β, γ-hybrid peptides into hairpins. Front. Chem., 2020, 8, 530083.
9. Sun, W.; Tang, F.; Cui, J.-X.; Lu Z.-L.*. Fluorescent Nanoparticles for Targeted Tumor Imaging and DNA Tracking Gene Delivery In Vitro/In Vivo. ACS Omega, 2020, 5, 31700-31705.
10. Ma, L.-L.; Tang, Q.; Liu, M.-X.; Liu, X.-Y.; Liu, J.-Y.; Lu Z.-L.*; Gao, Y.-G.*; Wang, R.*[12]aneN3-Based Gemini-Type Amphiphiles with Two-Photon Absorption Properties for Enhanced Nonviral Gene Delivery and Bioimaging. ACS Appl. Mater. Interf., 2020, 12, 40094-40107.
11. Ma, L.-L.; Liu, M.-X.; Liu, X.-Y.; Sun, W.; Lu Z.-L.*; Gao Y. G.*; He, L.* Macrocyclic polyamine [12]aneN3 modified triphenylamine-pyrazine derivatives as efficient non-viral gene vectors with AIE and two-photon imaging properties. J. Mater. Chem. B, 2020, 8, 3069-3079.
12. Sun, W.; Liu, X.-Y.; Ma, L.-L.; Lu Z.-L.* Tumor targeting gene vector for visual tracking of Bcl-2 siRNA transfection and anti-tumor therapy. ACS Appl. Mater. Interfaces, 2020, 12, 10193-10201.
13. Wang, Q.-H; Zhong, Y.-L.; Miller, D. P.; Lu, X.-L.; Tang, Q.; Lu Z.-L.; Zurek, E.; Gong, B.*; Liu, R.* Self-assembly and molecular recognition in water: Tubular stacking and guest-templated discrete assembly of water-soluble, shape- persistent macrocycles. J. Am. Chem. Soc., 2020, 142，2915-2924.
14. Tang, Q.; Zhong, Y. -L.; Miller, D. P.; Liu, R.; Zurek, E.; Lu Z.-L.*; Gong, B.* Reverse turn foldamers: An expanded β-turn motif reinforced by double hydrogen bonds. Org. Lett., 2020, 22，1003-1007.
15. Liu, M.-X.; Ma, L.-L.; Liu, X.-Y.; Liu, J.-Y.; Lu Z.-L.*; Liu, R.; He, L.* Combination of [12]aneN3 and triphenylamine-benzylideneimidazolone as nonviral gene vectors with two-photon and AIE properties. ACS Appl. Mater. Interfaces, 2019, 11, 42975-42987.
16. Zhang, Y.-K.; Zhong, Y.-L.; Connor, A. L.; Miller, D. P.; Cao, R.-K.; Shen, J; Song, B.; Baker, E. S.; Tang, Q.; Pulavarti, S. V. S. R. K.; Liu, R.; Wang, Q.-W.; Lu Z.-L.; Szyperski, T.; Zeng, H.-Q.; Li, X.P.; Smith, R. D.; Zurek, E.; Zhu, J.*; Gong, B.* Folding and assembly of short α, β, γ-hybrid peptides: Minor variations in sequence and drastic differences in higher-level structures. J. Am. Chem. Soc., 2019, 141, 14239-14248.
17. Sun, W.; Liu, X.-Y.; Cui, J.-X.; Ma, L.-L.; Zhang, Y.; Lu Z.-L.*; He, L.*, Mitochondria targeting two-photon fluorescent molecules for gene transfection and biological tracking. J. Mater. Chem. B , 2019, 7, 4309-4318.
18. Sun, W.; Shi, Y.-D.; Ding, A.-X.; Tan, Z.-L.; Chen, H.; Liu, R.*; Wang, R.; Lu Z.-L.*, Imaging viscosity and peroxynitrite by a mitochondria-targeting two-photon ratiometric fluorescent probe. Sensors and Actuators, B: Chem., 2018, 276, 238-246.
19. Ai, W.; Liu, Y.; Wang, Q.; Lu Z.-L.*; Liu, Q.*, Cu-Catalyzed redox-neutral ring cleavage of cycloketone O-acyl oximes: Chemodivergent access to distal oxygenated nitriles. Org. Lett. , 2018, 20, 409-412.
20. Shi, Y.-D.; Tang, Q.; Jiang, Y.-F.; Pei, Q.; Tan, H.-W.; Lu Z.-L.*; Gong, B.*, Effective formation of stable and versatile double-stranded β-sheets templated by a hydrogen-bonded duplex. Chem. Comm., 2018, 54, 3719-3722.